Hi Kevin,
Section 3.3.10 in the AAVSO CCD/CMOS Photometry guide is very informative with regards to the Gain and Offset settings in CMOS cameras:
Once you choose a gain and offset, just stick with it for all lights and calibration files.
With regards to temperature, just go with a value that your camera can cool to reliably. I use both -10C and -20C with my CCD. I use -10 in the Summer months when I find the camera can’t cope with -20. I have a QHY268C CMOS camera which I image with and I find that it can’t get down reliably cooler than -15C, so I tend to stick with -10.
Binning – I use both 1×1 and 2×2 for fainter targets.
Cheers
Ian.