Yes, it’s going to be a challenge. The attached plots show the visibility from my observatory in Chelmsford to give some idea. These show the altitude of the Orion spacecraft, the Sun and the Moon at the date shown along the bottom. On the night of the launch Orion is around 12 deg up at nautical twilight and descending. I don’t know how bright it will be but at 20h on the day of launch it will only be 10 deg up from here and it is already 79000 km away. The ISS at this distance would be around 4th mag and Orion is a lot smaller than the ISS.
By the time the circumstances get better it is far away and close to the Moon as you can see from the second plot.
I would love to be proven wrong and would be very impressed if anyone gets this from the UK!