I have imaged with various Canon DSLR’s over the past few years I have had to rely upon software to fix as far as possible any defects in my images, hot pixels & amplifier glow on the older cameras especially. I have now started to use calibration frames and to be honest there are more benefits than disincentives in my opinion even though my latest camera has the best sensor from a technical point of view
I did a quick poll at my Astronomy club tonight amongst the DSLR users, most did not use calibration frames, but acknowledged they need to get into the habit of calibrating their data to get the best results. There is nothing difficult about calibration frames compared to focussing on a subject you cannot see in the viewfinder or looks grim on the rear screen. Calibration frames are easy especially with the DSLR control programmes now available.