I use the ZWO ASI1600MM for

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#583807
James Screech
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I use the ZWO ASI1600MM for variable star photometry, you need to keep the gain low as increasing it will reduce the signal to noise ratio. I mainly use a gain of 0 and at most 80, you basically need to capture as many photons as possible without saturating the sensor. Increasing the gain does not increase the number of photons captured, it reduces them, that in turn means that the SNR is less.