At the risk of triggering a major debate, my experience of Windows 10 running my astronomy software and my telescope in my observatory has actually been pretty good. The only software I use that does not simply run is AIP4Win.
Though Windows 10 has the very annoying habit of wanting to run updates every few months without giving the option to postpone or disable updates. I am sure that alone is enough to put many off using it on an observatory computer.
Cheers,
Andy