Hi Connor,
Not necessarily binaries, but some variables which are good to start doing photometry on with the default S50 settings (i.e. 10s exposures) are:
T CrB
RY Leo
TX CVn
V UMa
U Boo
OO Aql
SW Cyg
BR Cyg
These all fall in a useful magnitued range to analyse each of the 10s exposures, and a good starting place I feel as no stacking should be necessary under reasonable conditions. If there is concern around the photometry mode in the S50 these are all easy enough export from the scope and analyse using other software.